管理的仪器名称：

[1]色谱质谱联用仪-QTRAP 6500

[2]Olink-PEA-靶向蛋白质组

开展的服务：

[1]目标小分子靶向LC-MS/MS检测

[2]Olink-PEA-靶向蛋白质组

可服务的新技术新方法：

[1]药物、代谢小分子等目标小分子定量检测方法开发及应用

[2]Olink中 Target 96可提供心脏代谢、心血管、代谢、细胞调节、发育、免疫反应、肿瘤免疫、炎症、肿瘤、器官损伤、神经系统疾病等不同的场景进行应用。Target 96包括92个蛋白生物标志物的检测，不同的检测panel针对特定的疾病或生物通路。

案例：

[1] Ming H, Tan J, Cao S Y ,et al.NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis[J].Nature Metabolism, 2025, 7(1):120-136.DOI:10.1038/s42255-024-01179-5.

LC-MS/MS检测二十种常见氨基酸

[2] Wu R, Sun C, Chen X, et al.NSUN5/TET2-directed chromatin-associated RNA modification of 5-methylcytosine to 5-hydroxymethylcytosine governs glioma immune evasion[J].Proceedings of the National Academy of Sciences, 2024, 121(14):12.DOI:10.1073/pnas.2321611121.

LC-MS/MS检测RNA修饰

代表论文：

[1] Yue Liu; Wang Xiaoyu; Yanqiu Gu et al.; Covalent Design of Cell Membrane Stationary Phase with

Enhanced Stability for Fast Screening P-Glycoprotein Inhibitors, BIO MATERIALS, 2020, 2020(3): 5000-5006

[2] Wang, Xiao-Yu; Ding, Xuan; Yuan, Yong-Fang et al. Comprehensive two-dimensional APTES decorated MCF7-cell membrane chromatographic system for characterizing potential anti-breast cancer components from Yuanhu-Baizhi herbal medicine pair, JOURNAL OF FOOD AND DRUG ANALYSIS,2018, 2(26): 823-833

[3]王晓宇; 晏国全; 周新文; 杨芃原 ; 化学裂解结合生物质谱对多肽二硫键的定位, 高等学校化学学报, 2020.夏季, 41(7): 1505-1512