管理的仪器名称：

徕卡SP8共聚焦显微镜  科研2号楼A栋CB3-005-002

安捷伦气质联用仪    科研2号楼A栋CB2-021

开展的服务：

1.徕卡SP8共聚焦显微镜

可用于观察细胞内的各种结构，如线粒体等细胞器的形态和分布，细胞骨架；对神经元进行成像，研究神经元的形态、突触的结构和功能

心肌细胞钙火花；生物材料的3D拍摄，如微球；类器官大面积拼接；斑马鱼胚胎,迁移体荧光等

2. 安捷伦气质联用仪

检测三羧酸循环代谢物，常见氨基酸，短链脂肪酸，有机酸类

可服务的新技术新方法：

案例（自己排序）：

1. Yu B, Pei C, Peng W, Zheng Y, Fu Y, Wang X, Wang W, Wang Z, Chen Y, Wang Q, Zhuma K, Gao Y, Xing Y, Jiao M, Liu R, Luo F, Zhang D, Qie J, Yang H, Jin M, Wang L, Chu Y. Microbiota-derived butyrate alleviates asthma via inhibiting Tfh13-mediated IgE production. Signal Transduct Target Ther. 2025 Jun 6;10(1):181. doi: 10.1038/s41392-025-02263-2. PMID: 40473603; PMCID: PMC12141656.

2. Xu C, Li C, Chen J, Xiong Y, Qiao Z, Fan P, Li C, Ma S, Liu J, Song A, Tao B, Xu T, Xu W, Chi Y, Xue J, Wang P, Ye D, Gu H, Zhang P, Wang Q, Xiao R, Cheng J, Zheng H, Yu X, Zhang Z, Wu J, Liang K, Liu YJ, Lu H, Chen FX. R-loop-dependent promoter-proximal termination ensures genome stability. Nature. 2023 Sep;621(7979):610-619. doi: 10.1038/s41586-023-06515-5. Epub 2023 Aug 9. Erratum in: Nature. 2025 Feb;638(8049):E1. doi: 10.1038/s41586-025-08606-x. PMID: 37557913; PMCID: PMC10511320.

3. Xu Y, Li J, Wang Z, Lu R, Liu Y, Wang M, Li H, Zhao R, Feng W. Ablation of dysmorphic neurons is a safe and effective treatment for focal cortical dysplasia II. Mol Ther. 2025 Sep 3;33(9):4414-4430. doi: 10.1016/j.ymthe.2025.05.023. Epub 2025 May 27. PMID: 40437754; PMCID: PMC12432865.

4. Cheng ZL, Zhang S, Wang Z, Song A, Gao C, Song JB, Wang P, Zhang L, Zhou Y, Shan W, Zhang C, Zhang J, Sun Y, Xu Y, Lan F, Zhong M, Lyu LD, Huang G, Chen FX, Li G, Wang Z, Chen F, Xue J, Shi J, Liu Y, Lin Z, Wu D, Na J, Chen LL, Guan KL, Xiong Y, Ye D. Pathogen-derived glyoxylate inhibits Tet2 DNA dioxygenase to facilitate bacterial persister formation. Cell Metab. 2025 May 6;37(5):1137-1151.e5. doi: 10.1016/j.cmet.2025.01.019. Epub 2025 Mar 3. PMID: 40037360.

5. Fu M, Zhang M, Zhang L, Feng Y, Gao C, Xu H, Zhang J, Zhang H, Peng T, Chu Y, Wu Y, Wang P, Ye D, Mao Y, Hua W. Transketolase attenuates the chemotherapy sensitivity of glioma cells by modulating R-loop formation. Cell Rep. 2025 Jan 28;44(1):115142. doi: 10.1016/j.celrep.2024.115142. Epub 2025 Jan 9. PMID: 39792560.

6. Xie Y, Han J, Wang Q, Fang X, Pan B, Han D, Li J, Shao W, Hong X, Tu W, Geng W, Li W, Tian Z, Chen R, Xu Y, Kan H. Electroacupuncture alleviates diesel exhaust particles-induced inflammatory response in lung through dopamine inhibition of NLRP3 signaling pathway. Ecotoxicol Environ Saf. 2025 May;296:118184. doi: 10.1016/j.ecoenv.2025.118184. Epub 2025 Apr 14. PMID: 40222111.

7. Yang X, Nie W, Wang C, Fang Z, Shang L. Microfluidic-based multifunctional microspheres for enhanced oral co-delivery of probiotics and postbiotics. Biomaterials. 2024 Jul;308:122564. doi: 10.1016/j.biomaterials.2024.122564. Epub 2024 Apr 3. PMID: 38581763.

8. Long Y, Zhu Z, Zhou Z, Yang C, Chao Y, Wang Y, Zhou Q, Wang MW, Qu Q. Structural insights into human zinc transporter ZnT1 mediated Zn2+ efflux. EMBO Rep. 2024 Nov;25(11):5006-5025. doi: 10.1038/s44319-024-00287-3. Epub 2024 Oct 10. PMID: 39390258; PMCID: PMC11549101.

所获奖励：

2023-2025年度校级优秀个人